Port Musgrave is a shallow, almost enclosed, estuarine bay located on the western coast of the Cape York Peninsula in Far North Queensland, Australia.
Two major rivers, the Wenlock and the Ducie, discharge into it. The bay itself and the area surrounding it are defined as the Port Musgrave Aggregation DIWA nationally important wetland. The surrounding area is rich in freshwater swamps, while the estuary itself has tidal flats and mangroves, including stands of the Nipa Palm. It is an important breeding area for saltwater crocodiles. The small Aboriginal community of Mapoon lies on the southern shore of the bay.
