The Innoko River is a 500-mile (800 km) tributary of the Yukon River in the U.S. state of Alaska. It flows north from its origin south of Cloudy Mountain in the Kuskokwim Mountains and then southwest to meet the larger river across from Holy Cross.
Most of its upper portion flows through the Innoko National Wildlife Refuge. The entire river is within the Yukon–Koyukuk Census Area.
