The Macquarie River is a major perennial river located in the Midlands region of Tasmania, Australia.
The Macquarie River rises below Tooms Lake, near Hobgoblin and flows generally south and then north-west and through the town of Ross before reaching its confluence with the South Esk River near Longford. The Tooms, Blackman, Elizabeth, Isis and Lake rivers all are tributaries of the Macquarie. The river descends 472 metres over its 189-kilometre course.
