Pikes Creek (also known as Pike Creek) is a tributary of Harveys Creek in Luzerne County, Pennsylvania, in the United States. It is approximately 14.3 km long and flows through Lake Township, Lehman Township, Jackson Township, and Plymouth Township. The watershed of the creek has an area of 30 km2. It is designated as a High-Quality Coldwater Fishery and a Migratory Fishery, as well as being Class A Wild Trout Waters for part of its length. The creek has a 400-acre reservoir, which is known as the Pikes Creek Reservoir and supplies water to tens of thousands of people. A number of bridges have been constructed over the creek.
