The River Loxley is a river in the City of Sheffield, South Yorkshire, England.
Its source is a series of streams which rise some 10 miles (16 km) to the north-west of Sheffield on Bradfield Moors, flowing through Bradfield Dale to converge at Low Bradfield.
It flows easterly through Damflask Reservoir and is joined by Storrs Brook at Storrs, near Stannington, and the River Rivelin at Malin Bridge, before flowing into the River Don at Owlerton, in Hillsborough.
The Loxley valley provided the initial course of the Great Sheffield Flood, which happened after the Dale Dyke Dam collapsed shortly before its completion in March 1864.
