The Spercheios (Greek: Σπερχειός, Sperkheiós), also known as the Spercheus from its Latin name, is a river in Phthiotis in central Greece. It is 80 km (50 mi) long, and its drainage area is 1,830 km2 (710 sq mi).
The river begins in the Tymfristos mountains on the border with Evrytania and flows to the east through the village Agios Georgios Tymfristou, entering a wide plain. It flows along with the towns Makrakomi and Leianokladi, and south of the Phthiotidan capital Lamia. The river flows through an area of former wetlands, that have been reclaimed for agriculture.
It empties into the Malian Gulf of the Aegean Sea 13 kilometers (8 mi) southeast of Lamia. In antiquity, the mouth of the river was the site of Antikyra, which was famed for its black and white hellebore.
